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CAS RN: 68302-57-8 | 产品编码: A2401
Amlexanox
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| 产品编码 | A2401 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__1__4N__2O__4 = 298.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 68302-57-8 |
| Reaxys-RN | 556384 |
| PubChem物质ID | 160871486 |
| Merck Index (14) | 490 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 300 °C |
GHS
相关法规
| RTECS# | DJ3102000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Amlexanox: A Specific Inhibitor of IKKε and TBK1 with Anti-Allergic Activity
Amlexanox (AA-673) is an anti-inflammatory and anti-allergic agent. The precise mechanism of action is known, but recently in vitro studies have demonstrate that amlexanox is a specific inhibitor of the protein kinases IκB kinase-ε (IKKε) and TANK-binding kinase 1 (TBK1) resulting in the inhibition of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells. For your reference, [C2661] is a synthetic intermediate of amoxanox. (The product is for research purpose only.)
References
- Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase
- Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family
- Two distinct anti-allergic drugs, amlexanox and cromolyn, bind to the same kinds of calcium binding proteins, except calmodulin, in bovine lung extract
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in Vitro
- An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
- A validated stability indicating LC method for amlexanox in bulk drugs
参考文献
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