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| TCI Life Science News December 2021 | ||||
| 【At TCI, we support discovery in life sciences through our knowledge and expertise in organic small molecules. In this issue we focus on our extracellular matrix research reagents, bioactive small molecules, endoglycoceramidase ― hydrolytic enzymes specific to glycosphingolipids, and the latest edition of TCIMAIL. We also have thousands of other useful compounds available only at TCI for your research and development. | ||||
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Extracellular Matrix Research ReagentsThe extracellular matrix (ECM) is an essential element for higher organisms to form cells, tissues, and organs; and to control cell-cell connections and functions. The ECM also greatly affects several biological phenomena such as development, aging, inflammation, wound healing, and immunity. Glycosaminoglycans (GAG), such as chondroitin sulfate, hyaluronic acid and keratan sulfate, are major components of the ECM and play an important role in various functions. TCI offers anti-glycosaminoglycan antibodies and can also synthesize GAG having sulfate groups at a desired position and being composed of required sugar residues with high purity and large scale. For example, TCI offers sulfated hyaluronic acids with various sulfation degree which can be modified by changing the synthetic reaction. | ||||
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Bioactive Small MoleculesTCI has many biologically active small molecules for your research. Bioactive small molecules for epigenetic research, receptor tyrosine kinase (RTK) inhibitors, non-receptor tyrosine kinase (non-RTK) inhibitors, polyamines, antitumor ingredients and more are available. | ||||
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Endoglycoceramidase ― Hydrolytic Enzymes Specific to GlycosphingolipidsEndoglycoceramidase (EGCase) is a glycolipid-specific hydrolase that cleaves the glycosidic linkage between oligosaccharide and ceramide of various glycosphingolipids (GSLs). EGCases derived from the genus Rhodococcus are endo-type hydrolases and work under detergent-containing reactive conditions in vitro. For preparation of analytical oligosaccharide samples cleaved from glycolipids extracted from cells, recombinant EGCase (rEGCase II) [R0242] is the enzyme that has generally been used. Moreover, rEGCase I [R0240] is capable of releasing ceramides from organic glucosylceramide. To strip oligosaccharides from the surface of living cells without detergent reagents, the mixture reagents, rEGCase II assisted by Activator II [R0243] and rEGCase I assisted by Activator II [R0241] are helpful because Activator II replaces the surfactant as the enzyme-activating protein. | ||||
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TCI Chemistry Research: TCIMAIL 188Released in November 2021, TCI's latest issue features Prof. Nagatoshi Nishiwaki’s chemistry chat. We also feature research on:
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