Carbohydrate-Conjugated Magnetic Beads

　Carbohydrate-conjugated magnetic beads are a highly useful tool for isolation of cells and glycan-binding molecules^1,2) and 1 are superparamagnetic beads conjugated to stringently purified synthetic glycan. 1 have an average particle size of 1 μm, and can be used in a variety of applications like flow cytometry. In addition, the glycan moiety is bonded to the magnetic beads by a unique conjugation method, which does not require ring opening at the reducing end of the oligosaccharide. Therefore, 1 maintain a native carbohydrate structure. In addition to the glycan conjugates introduced here, custom synthesis of magnetic beads can be applied to meet customers’ requests.

References

• 1) Site-Specific Multivalent Carbohydrate Labeling of Quantum Dots and Magnetic Beads
• X.-L. Sun, W. Cui, C. Haller, E. L. Chaikof, ChemBioChem 2004, 5, 1593.
• 2) Selection of carbohydrate-binding cell phenotypes using oligosaccharide-coated magnetic particles
• P. D. Rye, N. V. Bovin, Glycobiology 1997, 7, 179.

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