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CAS RN: 89786-04-9 | Product Number: T3732
Tazobactam
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Purity: >97.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
A$116.00
|
2 | 29 | Contact Us | |
| 5G |
A$397.00
|
6 | 0 | Contact Us |
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* ChemSupply Australia Pty Ltd (Phone: 08-8440-2000 / email: sales@chemsupply.com.au)
| Product Number | T3732 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2N__4O__5S = 300.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 89786-04-9 |
| Reaxys Registry Number | 4787943 |
| PubChem Substance ID | 354335791 |
| Merck Index (14) | 9083 |
| MDL Number | MFCD00867002 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +162 to +167 deg(C=1, DMF) |
Properties (reference)
| Melting Point | 172 °C(dec.) |
| Specific Rotation | 162° (C=1,DMF) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | XI0191400 |
Transport Information:
| H.S.code* | 2941.10-000 |
Application
Tazobactam, A β-Lactamase Inhibitor for Antibiotics
Tazobactam and its sodium salt [T4106], β-lactamase inhibitors, are able to inhibit enzymes (β-lactamases) produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins. Therefore, it can increase antibacterial activity of antibiotics and also it can expend antibacterial spectrum and reduce adverse reaction, which has broad application prospect. Many combination agents with antibiotics have been developed against Pseudomonas aeruginosa or multidrug-resistant bacteria, such as MRSA. For your reference, related products (β-lactamase inhibitors for antibiotics) are sulbactam [S0868] and 3-aminophenylboronic acid [A1281].
References
- Kinetic interactions of tazobactam with β-lactamases from all major structural classes
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli (a review)
- New β-lactam-β-lactamase inhibitor combinations in clinical development (a review)4
- β-Lactamase Inhibitors: An Update
Application
Tazobactam, A β-Lactamase Inhibitor for Antibiotics
Tazobactam, a β-lactamase inhibitor, is able to inhibit enzymes (β-lactamases) produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins. Therefore, it can increase antibacterial activity of antibiotics and also it can expend antibacterial spectrum and reduce adverse reaction, which has broad application prospect. Many combination agents with antibiotics have been developed against Pseudomonas aeruginosa or multidrug-resistant bacteria, such as MRSA. For your reference, related products (β-lactamase inhibitors for antibiotics) are sulbactam [S0868] and 3-aminophenylboronic acid [A1281].
References
- Kinetic interactions of tazobactam with β-lactamases from all major structural classes
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli (a review)
- New β-lactam-β-lactamase inhibitor combinations in clinical development (a review)
- β-Lactamase Inhibitors: An Update
PubMed Literature
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