TCI Chemistry News
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February 2023
TCI offers an extensive catalog of over 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry topics as follows:
- RNA Base-modified Nucleoside Triphosphate for mRNA Medicine Development
- Reagent for Primary Sulfonamide Synthesis
- TEMPO Oxidation Utilizing Iodobenzene Diacetate as a Reoxidant
- Regioselective Silylation of an Unprotected Carbohydrate Using the Boronic Acid and the Phosphine Oxide
RNA Base-modified Nucleoside Triphosphate for mRNA Medicine Development
RNA base-modified nucleoside triphosphates are applied to in vitro transcription (IVT) of RNA medicines. mRNA medicines have attracted attention as vaccines against COVID-19. Moreover, the potential of mRNA medicine is expected for new therapies. In existing mRNA vaccines, uridine is replaced by N1-methyl pseudouridine, which suppresses immunogenesis derived from mRNA. TCI's N1-methyl pseudouridine 5'-triphosphate sodium salt [M3544] have passed DNase and RNase contamination tests and a function test in IVT.
Reagent for Primary Sulfonamide Synthesis
tBuONSO [U0150] is utilized as a reagent for primary sulfonamide synthesis. tBuONSO reacts with Grignard reagents or organolithium reagents to give sulfonamides via nucleophilic attack on the sulfur atom of tBuONSO and successive elimination of isobutene. Organometallic reagents with various carbon skeletons such as aryl, heteroaryl, cyclopropyl, even sterically hindered isopropyl and tert-butyl groups are applicable.
TCI Practical Example: TEMPO Oxidation Utilizing Iodobenzene Diacetate as a Reoxidant
We are proud to present the TEMPO [T1560]-catalyzed oxidation of 1-naphthalenemethanol to a 1-naphthaldehyde by using iodobenzene diacetate [I0330]. TCI has many oxidation organocatalysts; please see the product brochure for oxidants here.
TCI Practical Example: Regioselective Silylation of an Unprotected Carbohydrate Using the Boronic Acid and the Phosphine Oxide
TCI introduces the selective tert-butyldiphenylsilylation of the 3-position hydroxy group of methyl α-L-fucopyranoside by using the co-catalyst system of 4-(dimethylamino)phenylboronic acid [D4428] and tributylphosphine oxide [T0921]. You can find other silylation reagents for protection of hydroxyl groups. » TCI eNewsletter Back Issues
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