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CAS RN: | Product Number: M3544
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]
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Purity:
Synonyms:
- [(2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl]methyl Tetrahydrogen Triphosphate Sodium Salt (ca. 100mM in Water)
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 0.01ML |
$100.00
|
Contact Us | 2 | ≥60 |
|
| 0.25ML |
$900.00
|
1 | 3 | ≥80 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | M3544 |
| Molecular Formula / Molecular Weight | C__1__0H__1__7N__2O__1__5P__3·xNa |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Related CAS RN | 1428903-59-6&1931922-77-8 |
Specifications
| Appearance | Colorless to Almost colorlessclear liquid |
| Purity(HPLC) | min. 95.0 area% |
| Concentration(HNMR) | 0.100 to 0.110 mol/L |
| DNase detection test | to pass test |
| RNase detection test | to pass test |
| Transcription test | to pass test |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.4400 |
Application
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water): A Modified Nucleotide for the Development of Next-Generation Vaccines
In recent years, numerous studies have demonstrated that mRNA has outstanding abilities to elicit potent immune responses, making it a viable new platform for the development of next-generation vaccines.1) There are further reports on the incorporation of modified nucleobases into mRNA which provide advantages for the generation of potent and long-lived antibody responses. This product is the 5'-triphosphate sodium salt of 1-methylpseudouridine (m1Ψ) [M3387] which enhances immune evasion, protein production, and consequently improves vaccine efficacy.2,3) We confirm that this product (m1Ψ-triphosphate) is used for the incorporation of it into mRNA by RNA polymerase, as well as transcription.
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
- 3) N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells
PubMed Literature
Please visit the Pubchem page at this link.
Articles/Brochures
TCIMAIL
[Featured Products] RNA Base-modified Nucleoside Triphosphate for mRNA Medicine Development[Featured Products] Base-modified Ribonucleoside Triphosphates for mRNA Drug Discovery
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