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RNA base-modified nucleoside triphosphates are applied to in vitro transcription (IVT) of RNA medicines. mRNA medicines have attracted attention as vaccines against COVID-19, which caused a pandemic. Moreover, the potential of mRNA medicine is expected for new therapies. In existing mRNA vaccines, uridine is replaced by N¹-methyl pseudouridine, which suppresses immunogenesis derived from mRNA.

TCI's N¹-methyl pseudouridine 5'-triphosphate sodium salt have passed DNase and RNase contamination tests and a function test in IVT.

We manufacture N¹-methyl pseudouridine 5'-triphosphate sodium salt in-house from nucleosides as raw materials, and can offer various analogues and derivatives as well as scale-up manufacturing services.