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CAS RN: 2259-96-3 | Product Number: C3392
Cyclothiazide (mixture of isomers)
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Purity: >95.0%(HPLC)
Synonyms:
- 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-Dioxide (mixture of isomers)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$110.00
|
13 | 0 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$308.00
|
5 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | C3392 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6ClN__3O__4S__2 = 389.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2259-96-3 |
| Reaxys Registry Number | 722843 |
| PubChem Substance ID | 354335513 |
| Merck Index (14) | 2754 |
| MDL Number | MFCD00210192 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 %(total of isomer) |
| Elemental analysis(Nitrogen) | 10.20 to 11.20 % |
Properties (reference)
| Melting Point | 234 °C |
| Maximum Absorption Wavelength | 273 nm |
GHS
Related Laws:
| RTECS# | DK9610000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Cyclothiazide: A Benzothiadiazide Antagonist of AMPA Receptors
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (also known as AMPA receptors) are a class of ionotropic glutamate receptors, and major players in mediating basal synaptic transmission and synaptic plasticity in the mammalian CNS. AMPA-receptor modulation could be a way of adjusting the excitatory–inhibitory balance. Therefore, AMPA receptors are emerging as a new target for epilepsy, depression, etc. Cyclothiazide has been reported as a benzothiadiazide antagonist of AMPA receptors, and a promising tool for analysis of allosteric regulatory mechanisms at AMPA receptors. (The product is for research purpose only.)
References
- Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents
- Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants
- Mechanism of glutamate receptor desensitization
- AMPA receptor potentiators: application for depression and parkinson's disease (a review)
- Cyclothiazide (a review of the physical properties, methods of analysis, synthesis and stability of cyclothiazide)
- Preparative isolation of the eutomer of cyclothiazide by high-performance liquid chromatography on a cellulose-derived chiral stationary phase with toluene-acetone as the mobile phase
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