Bioisosteres are different substructures but have similar properties in vivo and are utilized in many drug discovery studies. In addition to classical bioisosteres for carboxyl groups and amide bonds, bioisosteres corresponding to heterocycles and benzene rings have been developed and utilized in recent years. We have a variety of bioisosteres for morpholine, piperazine, benzene, etc.

We are proud to present the 2,2,2-trifluoroethy etherification of 4'-hydroxyacetophenone using 2,2,2-trifluoroethyl triflate [T1604].

We introduce to present the intermolecular hydroamination of 4-methoxystyrene and piperidine catalyzed by Ir[(dF(Me)ppy)₂(dtbbpy)]PF₆ [B6254] as a photoredox catalyst.

We are proud to present the Suzuki-Miyaura cross-coupling reaction of 4-chlorobenzotrifluoride and phenylboronic acid using Palladium on carbon [P1785] as a catalyst. P1785 can be removed by filtration.