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CAS RN: 7226-77-9 | Product Number: D4220
2'-Deoxy-5-(hydroxymethyl)cytidine
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Purity: >98.0%(T)
Synonyms:
- 5-hmdC
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$192.00
|
1 | 1 | 10 |
|
| 200MG |
$636.00
|
1 | 1 | 24 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D4220 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__5N__3O__5 = 257.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 7226-77-9 |
| Reaxys Registry Number | 28741 |
| PubChem Substance ID | 253660378 |
| MDL Number | MFCD09842113 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 205 °C |
| Maximum Absorption Wavelength | 274(H2O) nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.4400 |
Application
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC): the Sixth Nucleoside of the Genome
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC) and its base 5-hydroxymethylcytosine (5-hmC) were recently discovered as an oxidation product of 2’-deoxy-5-methylcytidine [D3610] in mammalian DNA, particularly in stem cell DNA. The function of 5-hmdC is currently not clear, but it is assumed that in stem cells they might be intermediates of an active demethylation process. The detecting 5-hmdC in a genome has been investigated.
References
- The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
- 5-Hydroxymethylcytosine, the Sixth Base of the Genome (Minireview)
- 5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations
- Determination of genomic 5-hydroxymethyl-2'-deoxycytidine in human DNA by capillary electrophoresis with laser-induced fluorescence
- Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling
- Deamination, Oxidation, and C–C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.164] 5-hmdC : The Sixth Nucleoside of the Genome[Product Highlights] The Sixth Nucleoside of the Genome, 5-hmdC
Product Documents (Note: Some products will not have analytical charts available.)
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