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CAS RN: 32986-56-4 | 產品號碼: T2503
| 產品號碼 | T2503 |
| 純度/分析方法 | >94.0%(T) |
| 分子式 / 分子量 | C__1__8H__3__7N__5O__9 = 467.52 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 32986-56-4 |
| Reaxys-RN | 1357507 |
| PubChem Substance ID | 87560061 |
| Merck Index(14) | 9490 |
| MDL編號 | MFCD00077885 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 94.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +138.0 to +148.0 deg(C=4, H2O)(calcd.on anh.substance) |
| Water | max. 8.0 % |
性質
| 熔點 | 178 °C |
| 比旋光 [α]D | 143° (C=4,H2O) |
| 水溶性 | Soluble |
GHS
相關法規
| RTECS # | WK2100000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
RNA aptamer research
References
- Direct Selection of RNA Beacon Aptamers
- Specific binding of aminoglycoside antibiotics to RNA
Application
Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa
Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius, and is similar in structure to gentamicin [G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)
References
- Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use
- The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, and sisomicin (a review)
- Tobramycin Inhalation Powder: a novel drug delivery system for treating chronic Pseudomonas aeruginosa infection in cystic fibrosis
- Tobramycin Inhalation Powder: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
考研文獻
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