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CAS RN: 13292-46-1 | 產品號碼: R0079
| 產品號碼 | R0079 |
| 純度/分析方法 | >98.0%(T) |
| 分子式 / 分子量 | C__4__3H__5__8N__4O__1__2 = 822.95 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 13292-46-1 |
| Reaxys-RN | 5723476 |
| PubChem Substance ID | 87560354 |
| Merck Index(14) | 8216 |
| MDL編號 | MFCD00151389 |
產品規格
| Appearance | Orange to Amber to Dark red powder to crystal |
| Purity(HPLC) | min. 94.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 188 °C(dec.) |
| 溶解性（可溶於） | Dimethylformamide |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | VJ7000000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Rifampicin: A Rifamycin Antibiotic with Activity against a Wide Variety of Organisms including Tuberculosis Germs
Rifampicin (other name: rifampin) is a semisynthetic rifamycin antibiotic, which is chemically synthesized from rifamycin, which is isolated from a strain of the actinomycete Amycolatopsis mediterranei. Rifampicin has activity against a wide variety of organisms, including tuberculosis germs and Staphylococcus aureus, as well as in vitro activity against penicillin-resistant Streptococcus pneumoniae, and many Gram-negative bacteria. Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase, which is responsible for DNA transcription. In contrast, the corresponding mammalian enzymes are not affected by rifampicin. Bacterial resistance to rifampicin is caused by mutations leading to a change in the structure of the β subunit of RNA polymerase. Rifampicin acts as a cytochrome P450 3A4 (CYP3A4) inducer, which increase the activity of CYP3A4. Thus, rifampicin can cause drug interaction with other medications.
References
- Rifampin: A Semisynthetic derivative of rifamycin. Prototype for the future (a review)
- Rifampin, a useful drug for nonmycobacterial infections (a review)
- Rifampin: mechanisms of action and resistance
- Pharmacokinetic interactions with rifampicin: Clinical relevance
- Rifampin and rifabutin drug interactions. An update
考研文獻
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