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CAS RN: 219580-11-7 | 產品號碼: P2474
| 產品號碼 | P2474 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__2__8H__4__1N__7O__3 = 523.68 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 219580-11-7 |
| Reaxys-RN | 10130688 |
| PubChem Substance ID | 354335228 |
| MDL編號 | MFCD08705327 |
產品規格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
性質
| 熔點 | 86 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
Research on regenerative medicine
PD 173074 inhibits the differentiation of mouse and human embryo stem cells1,2) and human induced pluripotent stem cells.3)
References
- 1) The ground state of embryonic stem cell self-renewal
- 2) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
- 3) Virus-free induction of pluripotency and subsequent excision of reprogramming factors
Application
PD173074: A Selective VEGFR and FGFR Inhibitor
PD173074 is a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, and also a selective fibroblast growth factor receptor (FGFR) inhibitor. VEGF is a signalling protein that induces angiogenesis and endothelial cell proliferation and it plays an important role in regulating vasculogenesis. FGF is a carrier protein that regulates important biological processes including cell proliferation and differentiation during development and tissue repair. The human FGFR reportedly comprises of four family members, FGFR1, FGFR2, FGFR3 and FGFR4. Recently, the anti-tumor activities of PD173074, targeted neoangiogenesis and mitogenesis, have been reported. (The product is for research purpose only.)
References
- Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
- Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
- Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
- Cancer genomics and genetics of FGFR2 (Review)
- The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth in vitro and in vivo
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