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CAS RN: 59703-84-3 | 產品號碼: P1774
Piperacillin Sodium Salt
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| 產品號碼 | P1774 |
| 純度/分析方法 | >98.0%(N) |
| 分子式 / 分子量 | C__2__3H__2__6N__5NaO__7S = 539.54 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 59703-84-3 |
| 相關CAS RN | 61477-96-1 |
| Reaxys-RN | 5373920 |
| PubChem Substance ID | 87560271 |
| Merck Index(14) | 7463 |
| MDL編號 | MFCD00056867 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +170 to +190 deg(C=0.8, H2O)(calcd.on anh.substance) |
| Water | max. 5.0 % |
性質
| 熔點 | 185 °C(dec.) |
| 比旋光 [α]D | 180° (C=0.8,H2O) |
GHS
相關法規
| RTECS # | XI0180000 |
運輸資料
| HS編碼* | 2941.10-000 |
Application
Piperacillin Sodium: A Broad Spectrum Penicillin with an Increased Activity against Pseudomonas Aeruginosa
iperacillin sodium, a number of so-called broad spectrum penicillins, is chemically synthesized from 6-APA [A0800]. Piperacillin have an increased activity against many Gram-negative bacteria, especially Pseudomonas aeruginosa, Klebsiella pneumonia and Serratia marcescens. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Piperacillin is often used in combination with tazobactam [T3732] which is a β-lactamase inhibitor to increase the antibiotic spectrum of it. Piperacillin–tazobactam has a broad spectrum of antibacterial activity that includes Gram-positive and -negative aerobic and anaerobic bacteria.
References
- In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity
- In vitro and in vivo activity of piperacillin, a new broad-spectrum semisynthetic penicillin
- Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins (a review)
- Piperacillin/Tazobactam: A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential (a review)
- Permeations of antimicrobial agents through Pseudomonas aeruginosa biofilms. A simple method
考研文獻
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