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CAS RN: 284461-73-0 | 產品號碼: O0599
Sorafenib
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 500MG |
NT$10,520
|
6 | 26 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | O0599 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__1H__1__6ClF__3N__4O__3 = 464.83 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 284461-73-0 |
| Reaxys-RN | 9666200 |
| MDL編號 | MFCD06411450 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 203.0 to 207.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 205 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | US4588870 |
運輸資料
| HS編碼* | 2933.39-000 |
Application
Sorafenib: An Inhibitor of Multiple Protein Kinases
The Ras/Raf/MEK/ERK signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) inhibits intracellular Raf kinases (C-Raf, B-Raf and mutant B-Raf) and cell surface receptor tyrosine kinases (c-KIT, FLT- 3, RET, VEGFR-1, VEGFR- 2, VEGFR- 3, and PDGFR).1-4) Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis and apoptosis. In fact, sorafenib decreases tumor cell proliferation and angiogenesis in vitro. There are reports, that sorafenib also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.5) (The product is for research purpose only.)
References
- 1) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
- 2) Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5
- 3) Discovery and development of sorafenib: a multikinase inhibitor for treating cancer (a review)
- 4) Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling (a review)
- 5) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
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![Sorafenib [Optimized for Cell Culture]](/medias/Tci-300-O0672.jpg?context=bWFzdGVyfHJvb3R8OTI4MnxpbWFnZS9qcGVnfGFEZGhMMmd6T0M4NU5EZzRPRGt6TURVd09URXdMMVJqYVMwek1EQmZUekEyTnpJdWFuQm58MWVkNTVhYmIyMjYxNTU3Y2E0NmUxOTE4NDA0MWM4NzQzOWViYjkwMGVhMWVlYmMzOGFjYmMxMmEyMzQ4MjNiMg "Sorafenib [Optimized for Cell Culture]")