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CAS RN: 182004-65-5 | 產品號碼: N0966
KB-R 7943
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纯度/分析方法: >98.0%(HPLC)
別名
- 4-[(4-Nitrobenzyl)oxy]phenethyl Carbamimidothioate Methanesulfonate
- Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate
- S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
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產品規格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 9.50 to 10.30 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2930.90-900 |
Application
Na+/Ca2+交換機構 (NCX) の阻害剤
This compound (often called KB-R7943) is an inhibitor of the Na+/Ca2+ exchanger (NCX). The NCX system plays a pivotal role in regulating intracellular Ca2+ concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. NCX system performs a particularly important function in regulating cardiac contractility and electric activity. KB-R9743 appears to exhibit selectivity for Ca2+-influx-mode NCX activity (reverse mode of NCX).
References
- A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1
- Cardioprotective effects of KB-R7943: a novel inhibitor of the reverse mode of Na+/Ca2+ exchanger
- KB-R7943 block of Ca2+ influx via Na+/Ca2+ exchange does not alter twitches or glycoside inotropy but prevents Ca2+ overload in rat ventricular myocytes
- Cardiac Na+-Ca2+ exchange: Molecular and pharmacological aspects (a review)
- Na+/Ca2+ exchange as a drug target-insights from molecular pharmacology and genetic engineering (a review)
考研文獻
文章/手冊
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