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CAS RN: 155558-32-0 | 產品號碼: H1745
Hydroxyfasudil Hydrochloride
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| 產品號碼 | H1745 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__1__4H__1__7N__3O__3S·HCl = 343.83 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 155558-32-0 |
| PubChem Substance ID | 468592024 |
| MDL編號 | MFCD06411567 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 299 °C(dec.) |
GHS
相關法規
運輸資料
| HS編碼* | 2935.90-000 |
Application
Hydroxyfasudil Hydrochloride: An Active Metabolite of Fasudil, a Rho Kinase Inhibitor
Hydroxyfasudil hydrochloride is an active metabolite of fasudil [F0839 (HCl salt)], which is a potent and selective Rho kinase (a protein phosphatase) inhibitor. Hydroxyfasudil inhibits phosphorylation of myosin light chain, the final step in the vascular smooth muscle contractile mechanism, by inhibiting Rho kinase. Fasudil has been used as a vasodilator for the treatment of cerebral vasospasm. (The product is for research purpose only.)
References
- Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage
- Hydroxyfasudil, and active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
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