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CAS RN: 60142-96-3 | 產品號碼: G0318
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
性質
| 熔點 | 166 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | GU6496000 |
運輸資料
| HS編碼* | 2922.49-000 |
Application
Gabapentin: A γ-Aminobutyric Acid (GABA) Analog Anticonvulsant and Analgesic Agent
Gabapentin is a neurotransmitter γ-aminobutyric acid (GABA) [A0282] analog anticonvulsant and analgesic agent. Although the exact mechanism is unknown, gabapentin may reduce Ca2＋ currents into brain neurons through the binding to the α2δ subunit of voltage-dependent Ca2＋ channels and reduces the release of several monoamine neurotransmitters. Furthermore, gabapentin may increase the concentration and the rate of synthesis of GABA in brain. Although GABA does not cross the blood-brain barrier, gabapentin penetrates into the central nervous system. (The product is for research purpose only.)
References
- The novel anticonvulsant drug, gabapentin (Neurontin), binds to the α2δ subunit of a calcium channel
- A summary of mechanistic hypotheses of gabapentin pharmacology (a review)
- The mechanisms of action of Gabapentin (a review)
- Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection
- Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products
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