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CAS RN: 129453-61-8 | 產品號碼: F1144
| 產品號碼 | F1144 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__3__2H__4__7F__5O__3S = 606.78 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 25MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 129453-61-8 |
| Reaxys-RN | 7734375 |
| PubChem Substance ID | 468591825 |
| MDL編號 | MFCD00903953 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]25 | +108 to +115 deg(365nm, C=2, methanol) |
性質
| 水溶性 | Insoluble |
| Degree of solubility in water | 0.00001 g/l 25 °C |
| 溶解性（可溶於） | Methanol, Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H410 : Very toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | KG7623000 |
運輸資料
| UN編號 | UN3077 |
| 類別 | 9 |
| 包裝類別 | III |
| HS編碼* | 2937.29-000 |
Application
Fulvestrant: An Estrogen Receptors Antagonist with a Unique Structure and Mode of Action
Many breast cancers have estrogen receptors (ERs) and the growth of these tumors can be stimulated by estrogen. ER antagonists bind to ER and downregulate the ER protein in breast cancer cells. Fulvestrant (ICI 182,780) is an ER antagonist with a unique structure and mode of action. It not only binds competitively to the ER with high affinity, but also acts as a degradation inducer of ER with its long alkyl side chain. Therefore, fulvestrant has been reported to help circumvent resistance to “pure” ER antagonists, such as tamoxifen citrate [T2510]. For your reference, [D5471] is a key synthetic intermediate of fulvestrant. (The product is for research purpose only.)
References
- A Potent Specific Pure Antiestrogen with Clinical Potential
- Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens
- Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action (a review)
- Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Pharmacokinetic profile of intramuscular fulvestrant in advanced breast cancer
- Determination of Fulvestrant in Rat Plasma by LC-MS-MS: Application to a Pharmacokinetic Study
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