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CAS RN: 154598-52-4 | 產品號碼: E0997
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| Specific rotation [a]20/D | -93.0 to -98.0 deg(C=1,MeOH) |
性質
| 熔點 | 138 °C |
| 比旋光 [α]D | -95° (C=1,MeOH) |
| Maximum Wavelength | 247(MeOH) nm |
| 水溶性 | Insoluble |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | DM3440000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Efavirenz: a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
Efavirenz is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) which shows good inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). RT is an essential viral enzyme which transcribes viral RNA into DNA. Compared with first-generation NNRTIs such as nevirapine [N0922], efavirenz shows greater resilience to drug resistance mutations within HIV-1 RT. Efavirenz is not effective against HIV-2 RT and human DNA polymerase.
References
- Efavirenz
- Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase
- The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism:Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
- Efavirenz and CYP2B6 polymorphism: implications for drug toxicity and resistance
- The history of antiretrovirals: key discoveries over the past 25 years
考研文獻
文章/手冊
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