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CAS RN: 50-91-9 | 產品號碼: D2235
2'-Deoxy-5-fluorouridine
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產品號碼 | D2235 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__9H__1__1FN__2O__5 = 246.19 |
外觀與形狀(20°C) | Solid |
儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
包裝和容器 | 100MG-Glass Bottle with Plastic Insert (閲覽圖片), 1G-Glass Bottle with Plastic Insert (閲覽圖片), 500MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 50-91-9 |
Reaxys-RN | 90221 |
PubChem Substance ID | 87568673 |
SDBS (AIST Spectral DB) | 19323 |
Merck Index(14) | 4112 |
MDL編號 | MFCD00006530 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Melting point | 148.0 to 152.0 °C |
性質
熔點 | 150 °C |
比旋光 [α]D | 38° (C=1,H2O) |
水溶性 | Soluble |
溶解性(可溶於) | Alcohol, Acetone |
溶解性(不溶於) | Ether, Benzene, Chloroform |
GHS
圖形表示 | |
信號詞 | Danger |
危險性說明 | H301 : Toxic if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
RTECS # | YU7525000 |
運輸資料
UN編號 | UN2811 |
類別 | 6.1 |
包裝類別 | III |
HS編碼* | 2934.99-000 |
Application
Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase
Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)
References
- Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine
- Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors (a review)
- Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer (a review)
考研文獻
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