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CAS RN: 34233-69-7 | 產品號碼: C3891
Clozapine N-Oxide
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| 產品號碼 | C3891 |
| 純度/分析方法 | >95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__8H__1__9ClN__4O = 342.83 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 34233-69-7 |
| Reaxys-RN | 7044724 |
| MDL編號 | MFCD00210190 |
產品規格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | HP1760000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2933.59-000 |
Application
Clozapine N-Oxide: A Selective Activator of a Series of Engineered Muscarinic Acetylcholine Receptors
Clozapine N-oxide is a major and pharmacologically inert metabolite of clozapine [C2547], a dibenzodiazepine "atypical" antipsychotic agent.1,2) Recently, clozapine N-oxide has received attention as a selective activator of designer receptors exclusively activated by designer drugs (DREADDs), a series of engineered muscarinic acetylcholine receptors (mAChRs) that respond exclusively to the synthetic ligand clozapine N-oxide.3-5) (The product is for research purpose only.)
Reference
- 1) Metabolism and bioactivation of clozapine by human liver in vitro
- 2) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
- 3) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
- 4) Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
- 5) Modulating dopamine signaling and behavior with chemogenetics: concepts, progress, and challenges (a review)
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