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CAS RN: 163252-36-6 | 產品號碼: C3845
| 產品號碼 | C3845 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__3FN__2O__5 = 260.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 163252-36-6 |
| Reaxys-RN | 8153334 |
| MDL編號 | MFCD00935785 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation | -107 to -117 deg(C=0.2, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 196 °C |
GHS
相關法規
| RTECS # | UV9052000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Clevudine: An L-Configuration Thymidine Analog with Antiviral Activity
Clevudine (L-FMAU; 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil) is an unnatural L-configuration thymidine analog with potent anti-hepatitis B virus (HBV) activity in vitro and in vivo. There are reports that clevudine interferes with HBV replication by inhibiting the activity of viral DNA polymerase and reverse transcriptase. (The product is for research purpose only.)
References
- Use of 2'-fluoro-5-methyl-β-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
- Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent (a review)
- Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication
- Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo (a review)
- Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance (a review)
- Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development (a review)
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