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CAS RN: 73963-72-1 | 產品號碼: C2587
| 產品號碼 | C2587 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__7N__5O__2 = 369.47 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 73963-72-1 |
| Reaxys-RN | 3632107 |
| PubChem Substance ID | 160870980 |
| Merck Index(14) | 2277 |
| MDL編號 | MFCD00866780 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 158.0 to 162.0 °C |
性質
| 熔點 | 160 °C |
| Maximum Wavelength | 257(MeOH) nm |
| 水溶性 | Insoluble |
| 溶解性（微溶於） | Methanol |
| 溶解性（不溶於） | Ether |
GHS
相關法規
| RTECS # | VC8277500 |
運輸資料
| HS編碼* | 2933.99-000 |
Application
Cilostazol: A Selective Inhibitor of Cyclic Nucleotide Phosphodiesterase 3 (PDE3)
Cilostazol is originally developed as a selective inhibitor of cyclic nucleotide phosphodiesterase 3 (PDE3). PDE3 inhibition in platelets and vascular smooth muscle cells is expected to provide an antiplatelet effect and vasodilatation, with therapeutic focus on cAMP. Recently, it has been reported that cilostazol is effective in vascular dementia associated with a cerebral ischemia. (The product is for research purpose only.)
References
- Effect of cilostazol on platelet aggregation and experimental thrombosis
- Y. Kimura, T. Tani, T. Kanbe, K. Watanabe, Arzneim.-Forsch. 1985, 35, 1144.
- Effect of cilostazol, a cyclic AMP phosphodiesterase inhibitor, on the proliferation of rat aortic smooth muscle cells in culture
- Cilostazol as a unique antithrombotic agent
- Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain
- Cilostazol prevents amyloid β peptide25-35-induced memory impairment and oxidative stress in mice
Application
Dissolution Studies
Reference
- Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
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