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CAS RN: 147-94-4 | 產品號碼: C2035
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | C2035 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__9H__1__3N__3O__5 = 243.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 147-94-4 |
| 相關CAS RN | 69-74-9 |
| Reaxys-RN | 89175 |
| PubChem Substance ID | 87558791 |
| Merck Index(14) | 2784 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +155.0 to +162.0 deg(C=1, H2O) |
| NMR | confirm to structure |
性質
| 熔點 | 214 °C |
| 比旋光 [α]D | 158° (C=1,H2O) |
| Maximum Wavelength | 272(H2O) nm |
| 水溶性 | Soluble |
GHS
相關法規
| RTECS # | HA5425000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Cytarabine (ara-C): D-Arabinosyl Nucleoside exhibiting Anti-Leukemia and Anti-DNA Virus Activities
Certain D-arabinosyl nucleosides, notably cytarabine (ara-C) and vidarabine (ara-A) [V0098] are used as an anti-leukemia agent and an anti-DNA virus agent. Ara-C and ara-A are cell cycle phase-specific antineoplastic agents, affecting cells only during the S-phase of cell division. Intracellularly, ara-C and ara-A are converted into the 5-triphosphates (ara-CTP and ara-ATP), which are the active metabolites. The mechanism of actions are not completely understood, but it appear that ara-CTP and ara-ATP act through the inhibition of tumor cell or virus-induced DNA polymerases, competing with dCTP and dATP, respectively. Incorporation of them into DNA and RNA also contribute to their cytotoxicity. (The product is for research purpose only.)
References
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA) (a review)
- Ara-C: cellular and molecular pharmacology (a review)
- Acute Myeloid Leukemia (a review)
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