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CAS RN: 61-75-6 | 產品號碼: B6544
Bretylium Tosylate
![Bretylium Tosylate No-Image](/medias/Tci-440-B6544.jpg?context=bWFzdGVyfHJvb3R8MjIyNjB8aW1hZ2UvanBlZ3xhREZrTDJnM1lpODVORFF5TXpReE5qRTNOamswTDFSamFTMDBOREJmUWpZMU5EUXVhbkJufDljMGFiYWZlNjgwZDE2MTFkNjY5YzMzMjI5ZWYyMGEzOTM0MDUyOTE4OTJhYTM1ZjI5ZjJlM2JlOGYzMGIzN2I)
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產品號碼 | B6544 |
純度/分析方法 | >95.0%(HPLC)(qNMR) |
分子式 / 分子量 | C__1__8H__2__4BrNO__3S = 414.36 |
外觀與形狀(20°C) | Solid |
儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive |
CAS RN | 61-75-6 |
Reaxys-RN | 5704709 |
MDL編號 | MFCD00038731 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Purity(qNMR) | min. 95.0 % |
Melting point | 60.0 to 64.0 °C |
NMR | confirm to structure |
性質
熔點 | 62 °C |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | BO9450000 |
運輸資料
HS編碼* | 2923.90-000 |
Application
Bretylium Tosylate: A Class III Antiarrhythmic Agent
Bretylium tosylate is a class III antiarrhythmic agent with prominent experimental and clinical antifibrillatory activity. Its antiarrhythmic action is significantly different from that of other antiarrhythmic agents. It is an adrenergic neuron blocker that is selectively absorbed at peripheral adrenergic nerve terminals where it first releases norepinephrine [A0906] (sympathomimetic effect) and then produces adrenergic neuron blockade. It also acts by blocking K+ channels and is classified as a class III antiarrhythmic. (The product is for research purpose only.)
Reference
- Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias (a review)
- Bretylium tosylate: profile of the only available class III antiarrhythmic agent (a review)
- Potentially significant drug interactions of class III antiarrhythmic drugs (a review)
- Bretylium tosylate (A review on the description, physical properties, synthesis, analysis, stability, absorption, metabolism, and excretion.)
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