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CAS RN: 1190-53-0 | 產品號碼: B6007
Buformin Hydrochloride
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| 產品號碼 | B6007 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__6H__1__5N__5·HCl = 193.68 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (<0°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片）, 50MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 1190-53-0 |
| Reaxys-RN | 3627999 |
| PubChem Substance ID | 468590843 |
| Merck Index(14) | 1476 |
| MDL編號 | MFCD00045591 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 174.0 to 178.0 °C |
| Elemental analysis(Nitrogen) | 34.30 to 38.00 % |
性質
| 熔點 | 176 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 + H320 : Causes skin and eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
運輸資料
| HS編碼* | 2925.29-000 |
Application
Buformin Hydrochloride: A Biganide Antidiabetic
Buformin hydrochloride is a biganide antidiabetic such as metformin [M2009] and phenformin. They delay absorption of glucose from the gastrointestinal tract, increase insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose by the liver.1) Although, buformin and phenformin were withdrawn from the clinical market in many countries due to an elevated risk of causing lactic acidosis which is a condition characterized by overproduction of lactic acid.2,3) Meanwhile, it has been reported that biganide antidiabetics inhibit the growth and development of cancer.4,5) (The product is for research purpose only.)
References
- 1) Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
- 2) Buformin concentrations in a case of fatal lactic acidosis
- 3) Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase
- 4) Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation
- 5) Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat
- 6) Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column
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