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CAS RN: 3690-10-6 | Product Number: Z0022
Zebularine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-Deoxyuridine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
NT$4,480
|
9 | 3 | Contact Us | |
| 1G |
NT$15,200
|
33 | ≥40 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | Z0022 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__5 = 228.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3690-10-6 |
| Reaxys Registry Number | 751056 |
| PubChem Substance ID | 253660306 |
| MDL Number | MFCD04973699 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +156 ～ +166 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 158 °C(dec.) |
| Specific Rotation | 158° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | UW7539720 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Zebularine: An Effective Inhibitor of DNA Methylation
The main epigenetic modification is DNA methylation, and patterns of aberrant DNA methylation are now recognized to be a common hallmark of tumor cells. Zebularine, which is structurally 4-deamino cytidine, is a recently discovered mechanism-based inhibitor of DNA methylation. It is an effective inhibitor of cytidine deaminase and DNA cytosine methyltransferase.
References
- Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases
- Inhibition of DNA methylation and reactivation of silenced genes by zebularine
- Preferential response of cancer cells to zebularine
- Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
- Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
- The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
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