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CAS RN: 503468-95-9 | Product Number: N1110
NU 7441
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Purity: >98.0%(HPLC)
Synonyms:
- KU 57788
- 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$7,200
|
10 | 4 | It can be shipped in about 3-4 weeks after ordering | |
| 50MG |
NT$10,840
|
15 | 6 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is unavailable in the U.S.
| Product Number | N1110 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__1__9NO__3S = 413.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 503468-95-9 |
| Reaxys Registry Number | 9876245 |
| MDL Number | MFCD11983069 |
Specifications
| Appearance | White to Gray to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.00 to 3.80 % |
Properties (reference)
| Melting Point | 222 °C(dec.) |
| Maximum Absorption Wavelength | 233(EtOH) nm |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
CRISPR Genome Editing
DNA-dependent protein kinase (DNA-PK) inhibitor, NU 7441, reduces the frequency of non-homologous end joining (NHEJ) while increasing the rate of homology-directed recombination (HDR) following Cas9-mediated DNA cleavage.1)
References
- 1) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
Application
NU7441: DNA-dependent protein kinase (DNA-PK) inhibitor
Recently, the inhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. NU7441 (KU57788) is a potent and selective inhibitor of the DNA repair enzyme DNA-dependent protein serine/threonine kinase (DNA-PK) which is activated by DNA damage and mediates DNA double-strand break repair. (The product is for research purpose only.)
References
- Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
- Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
- Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441
- DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
- Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
Articles/Brochures
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