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CAS RN: 1101854-58-3 | Product Number: J0038
JZL 184
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4-Nitrophenyl 4-[Bis[benzo[d][1,3]dioxol-5-yl](hydroxy)methyl]piperidine-1-carboxylate
- 4-Nitrophenyl 4-[Bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
NT$6,920
|
18 | 0 | It can be shipped in about 2 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | J0038 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__2__4N__2O__9 = 520.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 1101854-58-3 |
| Reaxys Registry Number | 20284487 |
| MDL Number | MFCD11976911 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 127.0 to 131.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 129 °C |
GHS
Related Laws:
| RTECS# | TM6127800 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
JZL 184: A Potent and Selective Inhibitor of Monoacylglycerol Lipase (MAGL)
Endogenous cannabinoids, such as anandamide [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the cannabinoid receptors CB1 and CB2. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS) which is involved in a variety of physiological processes. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). JZL 184 is a potent and selective inhibitor of MAGL and has been reported to raise mice brain 2-AG levels by eight-fold without altering anandamide and to attenuate neuropathic pain. (The product is for research purpose only.)
References
- Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism
- Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
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