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CAS RN: 24424-99-5 | Product Number: D1547
Di-tert-butyl Dicarbonate [Boc-reagent for Amino Acid]
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Purity: >95.0%(T)
Synonyms:
- Boc2O
- Di-tert-butyl Pyrocarbonate
- Pyrocarbonic Acid Di-tert-butyl Ester
- DiBoc
- Boc Anhydride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25G |
$32.00
|
≥100 | ≥100 |
| 100G |
$91.00
|
7 | ≥100 |
| 500G |
$341.00
|
8 | ≥100 |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | D1547 |
| Purity / Analysis Method | >95.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__8O__5 = 218.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 24424-99-5 |
| Reaxys Registry Number | 1911173 |
| PubChem Substance ID | 87568033 |
| SDBS (AIST Spectral DB) | 22556 |
| MDL Number | MFCD00008805 |
Specifications
| Appearance | White or Colorless to Light yellow powder to lump to clear liquid |
| Purity(Morpholine Method) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 23 °C |
| Flash point | 47 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H330 : Fatal if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H228 : Flammable solid. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | HT0230000 |
Transport Information:
| UN Number | UN2930 |
| Class | 6.1 / 4.1 |
| Packing Group | II |
| H.S.code* | 2920.90-000 |
Application
TCI Practical Example: Boc Protection of an Amine Moiety Using Boc2O
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Used Chemicals
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Procedure
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To a solution of indole (200 mg, 1.71 mmol) in THF (2 mL) was added DMAP (21 mg, 0.17 mmol, 0.1 eq.) and Boc2O (467 mg, 2.13 mmol, 1.25 eq.) at r.t. and stirred overnight. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with water (15 mL) and brine (15 mL). Then the organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to give N-Boc-indole as a colorless liquid (392 mg, >99% yield).
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Experimenter’s Comments
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Gas was generated during the reaction.
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Analytical Data
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N-Boc-indole
1H NMR (270 MHz, CDCl3); δ 8.14 (d, 1H, J = 8.1 Hz), 7.59 (t, 1H, J = 4.1 Hz), 7.57 (d, 1H, J = 7.7 Hz), 7.32 (dt, 1H, J = 6.8, 1.4 Hz), 7.23 (dt, 1H, J = 7.7, 0.8 Hz), 6.58 (d, 1H, J = 4.1 Hz), 1.68 (s, 9H).
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Lead Reference/
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- Visible light-induced 3-sulfenylation of N-methylindoles with arylsulfonyl chlorides
Application
Selective Protection of Aromatic Amines
References
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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Other Documents
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