用于生物成像的荧光有机硅纳米粒子

有机硅纳米粒子因其100nm的直径，适用于生物分子的检测¹⁾。有机硅FITC (Ex_max: 492 nm, Em_max: 523 nm)和有机硅罗丹明B (Ex_max: 556 nm, Em_max: 579 nm)的表面被硫醇基官能化，使其易于作为荧光标记与抗体等生物分子相结合²⁾，从而使生物分子的检测成为可能。例如，有机硅纳米粒子通过与抗体结合，被用于细胞的荧光检测。也有报道称，给小鼠静脉注射的有机硅纳米粒子能在癌组织中蓄积，因此利用有机硅纳米粒子的强荧光信号的特性，可轻松实现癌组织的活体成像³⁾。

关键词

O0561

有机硅FITC

O0573

有机硅罗丹明B

文献

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