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CAS RN: 1380349-88-1 | 产品编码: T4126
N-(4E)-TCO-L-lysine
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| 产品编码 | T4126 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__2__6N__2O__4 = 298.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (分解),加热 |
| CAS RN | 1380349-88-1 |
| Reaxys-RN | 22744955 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2924.29-000 |
应用
Strain-Promoted Inverse Electron-demand Diels-Alder Cycloaddition (SPIEDAC) Reaction with Tetarazine
N-(4E)-TCO-L-lysine is an unnatural amino acid (UAA) which can be incorporated in proteins through genetic code expansion using a modified pair of tRNA/tRNA synthetase (tRNA/RS). N-(4E)-TCO-L-lysine has a strained alkene moiety, and reacts with tetrazines through strain-promoted inverse-electron-demand Diels-Alder cycloaddition (SPIEDAC) very rapidly. According to Plass et al. the reaction between N-(4E)-TCO-L-lysine and TAMRA-tetrazine occurred at k = 35000±3000 M-1 s-1.1)
References
- 1) Amino acids for Diels-Alder reactions in living cells
- 2) Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells
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