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CAS RN: 173903-47-4 | 产品编码: T3862
Tizoxanide
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
产品编码 | T3862 |
纯度/分析方法 | >95.0%(HPLC) |
分子式/分子量 | C__1__0H__7N__3O__4S = 265.24 |
外观与形状(20°C) | 固体 |
储存温度 | 冷藏 (0-10°C) |
应避免的情况 | 加热 |
包装和容器 | 25MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 173903-47-4 |
Reaxys-RN | 8324260 |
PubChem物质ID | 468592989 |
MDL编号 | MFCD07484970 |
技术规格
Appearance | White to Orange to Green powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Elemental analysis(Nitrogen) | 15.10 to 16.60 % |
物性(参考值)
熔点 | 254 °C |
GHS
象形图 | |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2934.10-000 |
应用
Tizoxanide: An Active Metabolite of Nitazoxanide, a Thiazolide Antiprotozoal and Antiviral Agent
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths.1,2) Following oral administration in animals, nitazoxanide is rapidly hydrolyzed to tizoxanide (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide (tizoxanide) against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems.3-5) Nitazoxanide (tizoxanide) is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)
References
- 1) In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- 2) In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis
- 3) Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- 4) Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level
- 5) Antiviral activity of substituted salicylanilides - a review
应用
Tizoxanide: An Active Metabolite of Antiprotozoal Nitazoxanide
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is a thiazolide antiprotozoal agent. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. (The product is for research purpose only.)
References
- Nitazoxanide: pharmacokinetics and metabolism in man
- The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro
- Validated and Optimized High-Performance Liquid Chromatographic Determination of Tizoxanide, the Main Active Metabolite of Nitazoxanide in Human Urine, Plasma and Breast Milk
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