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CAS RN: 168273-06-1 | 产品编码: R0205
Rimonabant
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| 产品编码 | R0205 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__1Cl__3N__4O = 463.79 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 168273-06-1 |
| Reaxys-RN | 7231571 |
| PubChem物质ID | 468592783 |
| MDL编号 | MFCD04034714 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | UQ6279632 |
运输信息
| HS编码* | 2933.39-000 |
应用
Rimonabant: A Selective Cannabinoid-1 Receptor (CB1) Antagonist.
Rimonabant (SR141716) is a selective cannabinoid-1 receptor (CB1) antagonist. CB1 is a G protein-coupled cannabinoid receptor that are found in the nervous system, and the body uses it to control food intake. It has been reported that rimonabant can help mammals to reduce food intake and to lose weight by blocking CB1 receptors. In clinical, rimonabant was withdrawn in 2008 due to serious psychiatric side effects. (The product is for research purpose only.)
References
- Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors
- Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists
- The psychiatric side-effects of rimonabant
- Development and validation of a high-performance liquid chromatographic method for bioanalytical application with rimonabant
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