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CAS RN: 135575-42-7 | 产品编码: P2534
Pneumocandin B0
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| 产品编码 | P2534 |
| 纯度/分析方法 | >96.0%(HPLC) |
| 分子式/分子量 | C__5__0H__8__0N__8O__1__7 = 1,065.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 135575-42-7 |
| Reaxys-RN | 4902219 |
| PubChem物质ID | 354335442 |
| MDL编号 | MFCD28168025 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Elemental analysis(Nitrogen) | 9.50 to 11.50 % |
物性（参考值）
| 最大吸收波长 | 276(MeOH) nm |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Pneumocandin B0: A Naturally Occurring Lipophilic Cyclic Peptide with Antifungal Activity
Pneumocandin B0 is a naturally occurring lipophilic cyclic peptide isolated from the fungus, Glarea lozoyensis. It is a potent antifungal agent and acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. Pneumocandin B0 is also used as a starting molecule for some semisynthetic antifungal agents, such as caspofungin. (The product is for research purpose only.)
References
- Pneumocandins from Zalerion arboricola. I. Discovery and isolation
- Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-β-D-glucan synthase
- Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola
- Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0
- Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study
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