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CAS RN: 180272-45-1 | 产品编码: P2215
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Optical purity(GC) | min. 98.0 ee% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | gt. 80.0 to 84.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 83 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.49-000 |
应用
A Key Synthetic Intermediate of Solifenacin Succinate
This product is a key synthetic intermediate of solifenacin succinate [S0944] which is a selective M3 muscarinic receptor antagonist used for the treatment of overactive bladder (OAB).
References
- Synthesis and Antimuscarinic Properties of Quinuclidin-3-yl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate Derivatives as Novel Muscarinic Receptor Antagonists
- One-Pot Racemization Process of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline: A Key Intermediate for the Antimuscarinic Agent Solifenacin
- A validated LC method for the chiral purity of (S)-1,2,3,4-tetrahydro-1-phenylisoquinoline: a key intermediate of solifenacin
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技术规格
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