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CAS RN: 28957-04-2 | 产品编码: O0387
Oridonine
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纯度/分析方法: >98.0%(HPLC)
别名：
- 冬凌草甲素
- (14R)-7α,20-环氧-1α,6β,7,14-四羟基贝壳杉-16-烯-15-酮
- (1α,6β,7α,14R)-7,20-环氧-1,6,7,14-四羟基贝壳杉-16-烯-15-酮
- (14R)-7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
- (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
产品文档：
| 产品编码 | O0387 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__0H__2__8O__6 = 364.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 28957-04-2 |
| Reaxys-RN | 1691227 |
| PubChem物质ID | 468592517 |
| MDL编号 | MFCD00221762 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -57.0 to -61.0 deg (C=0.1, ethanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 252 °C |
| 最大吸收波长 | 237 nm (EtOH) |
GHS
相关法规
| RTECS# | NZ8177000 |
运输信息
| HS编码* | 2932.99-000 |
应用
Oridonin: An Active Diterpene with NLRP3 Inhibitory Activity
Oridonin (or oridonine) is an active diterpene isolated from Rabdosia rubescens used as a traditional Chinese medicine. Oridonin has been reported to possess a broad range of biological activities including anti-inflammation, anti-bacterial, anti-neoplastic and neuroprotective effects. It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. Oridonin has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics (a review)
- Discovery and development of natural product oridonin-inspired anticancer agents (a review)
- Therapeutic potential of oridonin and its analogs: from anticancer and antiinflammation to neuroprotection
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors (a review)
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