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CAS RN: 7240-38-2 | 产品编码: O0353
Oxacillin Sodium Salt Monohydrate
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This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | O0353 |
| 纯度/分析方法 | >95.0%(T) |
| 分子式/分子量 | C__1__9H__1__8N__3NaO__5S·H__2O = 441.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 7240-38-2 |
| 相关CAS RN | 66-79-5&1173-88-2 |
| Reaxys-RN | 4287093 |
| PubChem物质ID | 87560310 |
| Merck Index (14) | 6904 |
| MDL编号 | MFCD00167146 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Specific rotation [a]20/D | +200.0 to +215.0 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | 3.5 to 5.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 188 °C(dec.) |
| 比旋光度 [α]D | 205° (C=1,H2O) |
GHS
相关法规
运输信息
| HS编码* | 2941.10-000 |
应用
Oxacillin Sodium: A β-Lactamase-Resistant Penicillin
Oxacillin sodium, an isoxazolyl penicillin, is chemically synthesized from 6-APA [A0800] and [M2996]. Oxacillin has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria, the same as penicillin G [P1770] [P1772]. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, oxacillin, cloxacillin [C2244] and methicillin are resistant to the enzymes (β-lactamases) which produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins, due to theirs large side-chain, which does not allow the β-lactamases to bind. However, with the widespread use of oxacillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (ORSA) have become increasingly prevalent worldwide.
References
- A survey of the kinetic parameters of class C β-lactamases. Penicillins
- Contributions of the AmpC β-lactamase and the acrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to β-lactams
- Methicillin (oxacillin)-resistant Staphylococcus aureus strains isolated from major food animals and their potential transmission to humans
- Detection of methicillin/oxacillin resistance in staphylococci
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