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CAS RN: 56391-57-2 | 产品编码: N1108
Netilmicin Sulfate
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| 产品编码 | N1108 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__4__1N__5O__7·2^^1/__2H__2SO__4 = 720.77 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 56391-57-2 |
| 相关CAS RN | 56391-56-1 |
| Reaxys-RN | 5710471 |
| PubChem物质ID | 354335742 |
| Merck Index (14) | 6479 |
| MDL编号 | MFCD01311715 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Specific rotation [a]20/D | +87.0 ～ +96.0 deg(C=3, water, calcd.on dried substance) |
| Water | max. 15.0 % |
| NMR | confirm to structure |
物性（参考值）
| 比旋光度 [α]D | 91° (C=3,H2O,calcd.on dried substance) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | WK2286000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Netilmicin Sulfate: An Aminoglycoside Antibiotic with Less Ear and Kidney Toxicity
Netilmicin sulfate, a semisynthetic 1-N-ethyl derivative of sisomicin sulfate [I1049], is an aminoglycoside antibiotic with action similar to gentamicin sulfate [G0383], but less ear and kidney toxicity. Netilmicin is active against most Gram-negative and Gram-positive Staphylococcus, including many gentamicin-resistant strains. Netilmicin interacts with the 30S subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. (The product is for research purpose only.)
References
- Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance
- Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use (a review)
- Determination of netilmicin sulfate by liquid chromatography with pulsed electrochemical detection
- Development and Validation of a RP-HPLC Method for the Estimation of Netilmicin Sulfate and its Related Substances using Charged Aerosol Detection
参考文献
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