Maximum quantity allowed is 999
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CAS RN: 114-80-7 | 产品编码: N0358
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 %(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 1.0 % |
| NMR | confirm to structure |
物性（参考值）
| 溶解性（可溶于） | 氯仿, 醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | BR3150000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2924.29-000 |
应用
競合的な抗コリンエステラーゼ阻害剤，ネオスチグミンブロミド
Neostigmine bromide, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine bromide has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine bromide induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine bromide used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433]. (The product is for research purpose only.)
References
- The direct action of prostigmine on skeletal muscle; its relationship to the choline esters
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood
- Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
参考文献
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技术规格
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