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CAS RN: 144481-98-1 | 产品编码: L0296
Landiolol Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 124.0 to 128.0 °C |
物性（参考值）
| 熔点 | 126 °C |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | DA8346700 |
运输信息
| HS编码* | 2934.99-000 |
应用
Landiolol Hydrochloride: A Highly Cardioselective, Short-Acting Adrenergic β1-Selective Antagonist
Landiolol hydrochloride (ONO-1101) is a highly cardioselective, short-acting adrenergic β1-selective antagonist (blocker). Landiolol reduces heart rate by selectively blocking β1 receptors located chiefly in the heart. It is reported that landiolol has 8-fold greater cardioselectivity than esmolol [E1106] in vitro. Landiolol is a short-acting agent since the ester group of landiolol is rapidly hydrolyzed to an inactivate metabolite by esterases in plasma and liver. Landiolol hydrochloride is used for the treatment of tachyarrhythmia and better control of heart rate in surgery. (The product is for research purpose only.)
References
- Development of a highly cardioselective ultra short-acting β-blocker, ONO-1101
- Electrophysiologic, cardiohemodynamic and β-blocking actions of a new ultra-short-acting β-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol
- Landiolol: A Review of its use in Intraoperative and Postoperative Tachyarrhythmias
- Detection of landiolol using high-performance liquid chromatography/fluorescence: A blood esterase-sensitive ultra-short-acting β1-receptor antagonist
- Validation of HPLC-UV methods for quantitatively determining landiolol and its major metabolite in human blood
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