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CAS RN: 1101854-58-3 | 产品编码: J0038
JZL 184
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纯度/分析方法: >95.0%(HPLC)(qNMR)
别名：
- 4-[双[苯并[d][1,3]二氧戊环-5-基](羟基)甲基]哌啶-1-甲酸4-硝基苯酯
- 4-[双(1,3-苯并二氧戊环-5-基)(羟基)甲基]-1-哌啶甲酸4-硝基苯酯
- 4-Nitrophenyl 4-[Bis[benzo[d][1,3]dioxol-5-yl](hydroxy)methyl]piperidine-1-carboxylate
- 4-Nitrophenyl 4-[Bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 25MG |
S$259.50
|
18 | 0 | 下单后约2周内可以发货 |
|
| 产品编码 | J0038 |
| 纯度/分析方法 | >95.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__2__7H__2__4N__2O__9 = 520.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 1101854-58-3 |
| Reaxys-RN | 20284487 |
| MDL编号 | MFCD11976911 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 127.0 to 131.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 129 °C |
GHS
相关法规
| RTECS# | TM6127800 |
运输信息
| HS编码* | 2934.99-000 |
应用
JZL 184: A Potent and Selective Inhibitor of Monoacylglycerol Lipase (MAGL)
Endogenous cannabinoids, such as anandamide [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the cannabinoid receptors CB1 and CB2. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS) which is involved in a variety of physiological processes. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). JZL 184 is a potent and selective inhibitor of MAGL and has been reported to raise mice brain 2-AG levels by eight-fold without altering anandamide and to attenuate neuropathic pain. (The product is for research purpose only.)
References
- Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism
- Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
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