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CAS RN: 3778-73-2 | 产品编码: I0713
Ifosfamide
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纯度/分析方法: >95.0%(GC)(T)
别名：
- 异环磷酰胺
- N,3-双(2-氯乙基)-1,3,2-氧氮膦杂环己烷-2-胺2-氧化物
- 3-(2-氯乙基)-2-[(2-氯乙基)氨基]-1,3,2-氧氮膦杂环己烷2-氧化物
- 异磷酰胺
- N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-Oxide
- 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2-oxazaphosphinane 2-Oxide
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产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 1G |
S$256.50
|
请联系我们 | ≥60 |
|
| 产品编码 | I0713 |
| 纯度/分析方法 | >95.0%(GC)(T) |
| 分子式/分子量 | C__7H__1__5Cl__2N__2O__2P = 261.08 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (分解),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3778-73-2 |
| Reaxys-RN | 5802893 |
| PubChem物质ID | 468592053 |
| Merck Index (14) | 4896 |
| MDL编号 | MFCD00057374 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 44.0 to 50.0 °C |
| Specific rotation | -1.0 to +1.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 48 °C |
| 水溶性 | 可溶 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | RP6050000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2934.99-000 |
应用
Ifosfamide: An Oxazophosphorine Antitumor Alkylating Agent
Ifosfamide is an oxazaphosphorine alkylating agent with a broad spectrum of antineoplastic activity. It is a prodrug that requires metabolic activation by hepatic cytochrome P450 isoenzymes to exert its cytotoxic activity. The exact mechanism of action of ifosfamide has not been determined, but among various metabolites, isophosphoramide mustard probably represents the most important cytotoxic compound able to produce irreparable cross-links between DNA strands caused by alkylation by the isophosphoramide mustard at guanine N-7 positions. In addition, mesna [M0913] is often used as a prophylactic agent for side effects of oxazophosphorine antitumor alkylating agents such as cyclophosphamide [C2236] and ifosfamide. (The product is for research purpose only.)
References
- Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer.
- Pharmacology of ifosfamide (a review)
- Simultaneous determination of cyclophosphamide, ifosfamide, doxorubicin, epirubicin and daunorubicin in human urine using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry: bioanalytical method validation
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