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CAS RN: 19767-45-4 | Product Number: M0913
Sodium 2-Mercaptoethanesulfonate
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Purity: >95.0%(T)
Synonyms:
- 2-Mercaptoethanesulfonic Acid Sodium Salt
- Mesna
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10G |
$93.00
|
3 | 3 | ≥100 |
|
| 25G |
$219.00
|
12 | 2 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | M0913 |
| Purity / Analysis Method | >95.0%(T) |
| Molecular Formula / Molecular Weight | C__2H__5NaO__3S__2 = 164.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 19767-45-4 |
| Reaxys Registry Number | 3657828 |
| PubChem Substance ID | 87572900 |
| Merck Index (14) | 5909 |
| MDL Number | MFCD00007535 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Iodometric Titration) | min. 95.0 % |
Properties (reference)
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | KI7968000 |
Transport Information:
| HS Number | 2930.90.9251 |
Application
Mesna: A Prophylactic Agent for Side effects of Oxazophosphorine Antitumor Alkylating Agents
Sodium 2-mercaptoethanesulfonate (Mesna) is a prophylactic agent for side effects of oxazophosphorine antitumor alkylating agents such as cyclophosphamide [C2236] and ifosfamide. Mesna binds to the toxic metabolites (the 4-hydroxy metabolite or acrolein) of them in the urine, and reduce the incidence of hemorrhagic cystitis and bladder cancer. (The product is for research purpose only.)
References
- Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention. III. Profile of action of sodium 2-mercaptoethanesulfonate (mesna)
- Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat
- Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: a data-driven review
- Facile and sensitive method for the determination of mesna in plasma by high-performance liquid chromatography with ultraviolet detection
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