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CAS RN: 498-02-2 | 产品编码: H0261
4'-Hydroxy-3'-methoxyacetophenone
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技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| Solubility in Methanol | faint turbidity |
物性（参考值）
| 熔点 | 115 °C |
| 沸点 | 300 °C |
| 最大吸收波长 | 383(MeOH) nm |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | AM8800000 |
运输信息
| HS编码* | 2914.50-000 |
应用
Apocynin: A Selective Inhibitor of NADPH Oxidase Activity
Apocynin, a methoxy-substituted catechol analog, is contained in the traditional medicinal plant Picrorhiza kurroa which has been used for the treatment of liver and heart problems. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is an enzyme that effectively reduces O2 to superoxide anion radical (O2–) by transferring one electron to oxygen from NADPH. The superoxide anion radical can be used by the immune system to kill bacteria and fungi. It has been reported that apocynin acts as an inhibitor of NADPH oxidase activity, and can decrease the production of superoxide anion radical from activated neutrophils and macrophages. The production of superoxide anion radical has also been shown to be associated with inflammation. Acutually, the anti-inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation. (A related compound: NADPH. 3Na Salt [T0521]) (The product is for research purpose only.)
References
- Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
- Apocynin: molecular aptitudes (a review)
参考文献
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