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CAS RN: 93479-97-1 | 产品编码: G0395
Glimepiride
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| 产品编码 | G0395 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__4H__3__4N__4O__5S = 490.62 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 93479-97-1 |
| Reaxys-RN | 7731873 |
| PubChem物质ID | 160870906 |
| Merck Index (14) | 4440 |
| MDL编号 | MFCD00878417 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 202.0 to 206.0 °C |
物性（参考值）
| 熔点 | 204 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（不溶于） | 甲醇, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | UX9363950 |
运输信息
| HS编码* | 2935.90-000 |
应用
Glimepiride: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Glimepiride (or glimperide) belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. In addition, extrapancreatic effects may also play a role in the activity of glimepiride. Glimepiride can stimulate glucose transport and lead to increased sensitivity of peripheral tissues to insulin. (The product is for research purpose only.)
References
- Special pharmacology of the new sulfonylurea glimepiride
- The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro
- Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade
- Glimepiride: a review of its use in the management of type 2 diabetes mellitus
- Sulfonylurea stimulation of insulin secretion (a review)
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
应用
Pharmacology Studies
References
- Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes
- Simultaneous determination of the sulfonylurea glimepiride and its metabolites in human serum and urine by high-performance liquid chromatography after pre-column derivatization
参考文献
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