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CAS RN: 6559-91-7 | 产品编码: D5653
4'-Demethylepipodophyllotoxin
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纯度/分析方法: >98.0%(HPLC)
别名：
- 4'-去甲基表鬼臼毒素
- (5R,5aR,8aR,9S)-9-羟基-5-(4-羟基-3,5-二甲氧苯基)-5,5a,8a,9-四氢呋喃并[3',4':6,7]萘并[2,3-d][1,3]二氧杂环戊烷-6(8H)-酮
- (5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
产品文档：
| 产品编码 | D5653 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__2__0O__8 = 400.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6559-91-7 |
| Reaxys-RN | 1358259 |
| PubChem物质ID | 468591478 |
| MDL编号 | MFCD00189421 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -68.0 to -60.0 deg(C=0.65, MeOH) |
物性（参考值）
| 熔点 | 255 °C |
| 比旋光度 [α]D | -64° (C=0.65,MeOH) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | LV2476200 |
运输信息
| HS编码* | 2932.99-000 |
应用
4'-Demethylepipodophyllotoxin: A Key Synthetic Intermediate for the Preparation of Podophyllotoxin-Type Anti-Tumor Agents
4'-Demethylepipodophyllotoxin is a key synthetic intermediate for the preparation of podophyllotoxin[P1771]-type anti-tumor agents, including etoposide [E0675]. 4'-Demethylepipodophyllotoxin is also an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. (The product is for research purpose only.)
References
- Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
- Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II
- Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
- Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives
- Structure of 4’-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
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技术规格
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