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CAS RN: 145108-58-3 | 产品编码: D5062
Dexmedetomidine Hydrochloride
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| 产品编码 | D5062 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__3H__1__6N__2·HCl = 236.74 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 145108-58-3 |
| 相关CAS RN | 113775-47-6 |
| Reaxys-RN | 8937629 |
| PubChem物质ID | 354333214 |
| Merck Index (14) | 2946 |
| MDL编号 | MFCD12912677 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| Melting point | 156.0 to 160.0 °C |
| Specific rotation [a]20/D | +49.0 to +54.0 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 158 °C |
| 比旋光度 [α]D | 51° (C=1,H2O) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NI5156750 |
运输信息
| HS编码* | 2933.29-000 |
应用
Dexmedetomidine Hydrochloride: A Potent and Selective α2-Adrenoceptor Agonist
Dexmedetomidine hydrochloride is a potent α2-adrenoceptor agonist, which produces and analgesia, about 8 times higher selective affinity for the α2/α1-adrenoceptor than clonidine [D1353]. Dexmedetomidine also binds to imidazoline receptors, based on the imidazole group. (The product is for research purpose only.)
References
- Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes
- Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.
- Assessment of the role of α2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
- The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
- Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation
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