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CAS RN: 50-91-9 | 产品编码: D2235
2'-Deoxy-5-fluorouridine
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| 产品编码 | D2235 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__9H__1__1FN__2O__5 = 246.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片）, 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50-91-9 |
| Reaxys-RN | 90221 |
| PubChem物质ID | 87568673 |
| SDBS (AIST Spectral DB) | 19323 |
| Merck Index (14) | 4112 |
| MDL编号 | MFCD00006530 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 148.0 to 152.0 °C |
物性（参考值）
| 熔点 | 150 °C |
| 比旋光度 [α]D | 38° (C=1,H2O) |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 醇, 丙酮 |
| 溶解性（不溶于） | 乙醚, 苯, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | YU7525000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2934.99-000 |
应用
Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase
Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)
References
- Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine
- Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors (a review)
- Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer (a review)
参考文献
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